NEP as Substituted Cathinone and Its Use

NEP as Substituted Cathinone and Its Use

N‐Ethyl Pentylone (NEP) is a relatively new and therefore less researched stimulant, which may be used in medical studies in a variety of ways. The chemical , also known as N-Ethyl-nor-pentylone, Ethyl-pentylone, and N-Ethylpentylone, belongs to the class of cathinones and has been shown to cause a range of stimulating effects. 

This research chemical was presented in 2016. This synthetic substance mimics or replaces the features of predecessors, both in terms of functioning and structure. Currently, data concerning the pharmacological properties of the chemical, metabolism, and toxicity with regard to humans is very limited. 


Generally, the effects produced by substance intake fall into three categories:

  • stimulating; 
  • euphoric;
  • entactogenic.

The chemical in question is a norepinephrine-dopamine reuptake inhibitor. This means that dopamine, a neurotransmitter linked to the pleasure and reward sectors of the human brain, is no longer reuptaken by its cells. This accumulation of neurotransmitter causes the mentioned state of euphoria. 

The third type of effects is explained by the inhibition of serotonin reuptake. In dosage from moderate to high, the chemical shows properties of inhibitor or releasing agent, which requires further confirmation. Here are the main effects reported by research participants to date:

  • stimulation and energy boost;
  • cognitive euphoria;
  • accelerated thinking;
  • immersion and focus;
  • improved analytical abilities;
  • enhanced appreciation of music; 
  • tingling;
  • tactile enhancement;
  • dry mouth and general dehydration, usually with excessive doses;
  • moderate vasoconstriction;
  • abnormal heartbeat;
  • higher blood pressure;
  • higher heart rate;
  • higher perspiration;
  • lowered appetite;
  • moderate enhancement of empathy and sociability.

There are, however, a few negative effects which are usually observed at excessive doses:

  • anxiety or depression;
  • headaches;
  • cognitive fatigue;
  • distorted perception of time;
  • erectile dysfunction (temporary);
  • teeth grinding.

Abuse and compulsive redosing must be prevented at all costs. 

Toxic Potential

These kinds of long-term effects have not yet been studied in a scientific environment, which is why the exact toxic dosage is unclear. Based on experience reports from early chemical takers, it could be suggested that such negative effects do, however, exist. They may be observed in cases of uncontrolled use and extreme dosage. When the dosage is low to medium and the intake is strictly controlled, they are not generally witnessed.   


A phenethylamine core has an alkyl group on its alpha carbon and an oxygen group on its beta one. In terms of structure, the molecule looks very similar to pentedrone, which is its constituent component. The only difference is the presence of an extra ethyl group located on the terminal nitrogen within the carbon chain. 

Due to such structure, the chemical is approximately three times more powerful than its constituent compound. Another chemical related to NEP is N-Ethylhexedrone. The effects of the two substances on research subjects are generally very similar. 


Since the compound is relatively new, it must be treated with extreme caution. Any kind of uncontrolled recreational use, as well as any human or animal consumption in general, are advised against. As the chemical has abuse potential, administering must be done in controlled research settings with constant supervision over the subjects’ reactions.

Leave a Reply

Your email address will not be published. Required fields are marked *