MDPHP as Cathinone Stimulator and Its Medical Use

MDPHP as Cathinone Stimulator and Its Medical Use

MDPHP which stands for 3′,4′-Methylenedioxy-α-pyrrolidinohexiophenone, is a research chemical belonging to the stimulant category. These are based on a cathinone that appeared on the market in the mid-20th century. It is informally referred to as “monkey dust” and is related to MDPV, a powerful stimulant with comparable but slightly softer effects on research subjects. Here is an overview of its use and effects in medical settings.

Media Coverage

Over the past few years, the media have been spreading rumors of alleged detrimental effects on the human psyche, including violent or suicidal inclinations. However, any such claims are baseless, as the said effects, while not typical for MDPHP, may theoretically only be achieved with extreme doses of the stimulant consumed over extended periods of time and in particular in sleep-deprived subjects. 


The substance is primarily used as an analog of MDPV when the latter is unavailable. It is currently classified as a “controlled substance” in Hungary and Japan, while a number of jurisdictions list it as “controlled under analog provisions”. MDPV is intended for research and medical purposes only. Neither human nor animal consumption is recommended due to the lack of studies into the effects of the novel stimulant. 

Generally, the history of medical use is very limited, with a few instances in Europe in 2014-2016. It is important to note that the batches produced at the time varied in terms of purity and content. Another factor complicating the research is that other cathinones have sometimes been sold under the name.

In terms of intake methods, inhalation must be avoided. It is essential to note that MDPHP must be subjected to heat in order to avoid decomposition. The latter would leave dark-colored residue with a highly unpleasant taste that cannot be used. 


Since MDPHP falls within the cathinone and pyrovalerone classes, its structure is therefore similar to α-PVP, α-PHP, and MDPV. The molecular formula of the compound is C17H23NO3, and the weight of each molecule is 289.375 g/mol.


Abuse of any stimulants, such as methamphetamine or cocaine, leads to dangerous effects. Hence, they must be used in a controlled medical environment and under constant professional supervision. The doses must be light and carefully adjusted based on the witnessed individual results. Redosing is only allowed every few hours to prevent overstimulation. 

Although doses over 100 mg have been reported, there are reasons to believe such amounts cause overdosing. Such experience details, therefore, should be considered with skepticism. A possible explanation of the high dosage could be a lack of purity or replacement of MDPHP with other stimulants. 

General Effects

Here are the most frequent favorable effects, based on experience reports available to date: 

  • stimulation;
  • motivation growth;
  • euphoria and positive mood;
  • sociability advance;
  • confidence increase;
  • sexual improvement.

There are, however, possible negative effects that are usually linked to uncontrolled usage. After consuming large doses, subjects may report anxiety and paranoia. Dry mouth, muscle tension, and unpleasant physical stimulation may also occur. Blood pressure and heart rate may rise, and restlessness may be observed. It is vital to prevent the development of compulsive redosing.

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